PDFs are available upon request.
*as corresponding author
2025
Atreyee Mishra, Dominic J Black, Thomas S Bradford, Karrera Y Djoko, Benjamin J Hofmann, Jamie J Hunter, Rianne M Lord, Robert Pal, Harvey J Smart, Tameryn Stringer, James W Walton. (2025) Copper pyrithione complexes with endoplasmic reticulum localisation showing anticancer activity via ROS generation. Chemical Science 16, 21104-21110.
Archie Howell, Safa Chogule, Karrera Djoko*. (2025) Copper homeostasis in Streptococcus and Neisseria: Known knowns and unknown knowns. Advances in Microbial Physiology 86, 99-140.
2023
YoungJin Hong, Eilidh S Mackenzie, Samantha J Firth, Jack RF Bolton, Louisa J Stewart, Kevin J Waldron, Karrera Y Djoko*. (2023) Mis-regulation of Zn and Mn homeostasis is a key phenotype of Cu stress in Streptococcus pyogenes. Metallomics 15(11), mfad064.
Ani Paloyan, Armen Sargsyan, Mariam D. Karapetyan, Artur Hambardzumyan, Sergei Kocharov, Henry Panosyan, Karine Dyukova, Marina Kinosyan, Anna Krueger, Cecilia Piergentili, Will A. Stanley, Karrera Y. Djoko, Arnaud Baslé, Jon Marles-Wright, Garabed Antranikian. (2023) Structural and biochemical characterisation of the N-carbamoyl-β-alanine amidohydrolase from Rhizobium radiobacter MDC 8606. FEBS J 290, 5566–5580
Karrera Y Djoko*. (2023) Control of nutrient metal availability during host-microbe interactions: beyond nutritional immunity. Journal of Biological Inorganic Chemistry 28, 451–456.
Louisa J Stewart, YoungJin Hong, Isabel R Holmes, Samantha J Firth, Yasmin Ahmed, Janet Quinn, Yazmin Santos, Steven L Cobb, Nicholas S Jakubovics, Karrera Y Djoko*. (2023) Salivary antimicrobial peptide Histatin-5 does not display Zn (II)-dependent or-independent activity against Streptococci. ACS Infectious Diseases 9(3), 631–642.
Atreyee Mishra, Karrera Y Djoko, Yi-Hsuan Lee, Rianne M Lord, Grace Kaul, Abdul Akhir, Deepanshi Saxena, Sidharth Chopra, James W Walton. (2023) Water-soluble copper pyrithione complexes with cytotoxic and antibacterial activity. Organic and Biomolecular Chemistry 21, 2539-2544.
Caroline Donaghy, Jose Gabriel Javellana, YoungJin Hong, Karrera Y Djoko, Alfredo M Angeles-Boza. (2023) The Synergy between Zinc and Antimicrobial Peptides: An Insight into Unique Bioinorganic Interactions. Molecules 28(5), 2156.
2022
Charlotte I Z O’Hern and Karrera Y Djoko*. (2022) Copper cytotoxicity: cellular casualties of noncognate coordination chemistry. mBio 13(3):e00434-22.
Stephan Brouwer, Magnus Jespersen, Cheryl-lynn Y Ong, David De Oliveira, Bernhard Keller, Amanda Cork, Karrera Y Djoko, Mark R Davies, Mark J Walker. (2022) Streptococcus pyogenes hijacks host glutathione for growth and innate immune evasion. mBio 13(3):e0067622.
Guillaume A Petit, Yaoqin Hong, Karrera Y Djoko, Andrew E. Whitten, Emily J Furlong, Airlie J McCoy, Jacqueline M. Gulbis, Makrina Totsika, Jennifer L Martin, Maria A Halili. (2022) The suppressor of copper sensitivity protein C from Caulobacter crescentus is a trimeric disulfide isomerase that binds copper (I) with subpicomolar affinity. Acta Crystallographica D78:337-352.
2020
Louisa J Stewart, Cheryl-lynn Y Ong, May M Zhang, Stephan Brouwer, Liam McIntyre, Mark R Davies, Mark J Walker, Alastair G McEwan, Kevin J Waldron, Karrera Y Djoko*. (2020) Role of glutathione in buffering excess intracellular copper in Streptococcus pyogenes. mBio 11:e02804-20.
2019
Andrew G Turner, Karrera Y Djoko, Y Ong Cheryl-lynn, Timothy C Barnett, Mark J Walker, Alastair G McEwan. (2019) Group A Streptococcus co-ordinates manganese import and iron efflux in response to hydrogen peroxide stress. Biochemical Journal 476(3):595-611.
Louisa J Stewart, Denis Thaqi, Bostjan Kobe, Alastair G McEwan, Kevin Waldron, Karrera Y Djoko*. (2019) Handling of nutrient copper in the bacterial envelope. Metallomics 11(1):50-63.
2018
Karrera Y Djoko, Maud ES Achard, Minh-Duy Phan, Alvin W Lo, Manfredi Miraula, Sasiprapa Prombhul, Steven J Hancock, Kate M Peters, Hanna E Sidjabat, Patrick N Harris, Nataša Mitić, Timothy R Walsh, Gregory J Anderson, William M Shafer, David L Paterson, Gerhard Schenk, Alastair G McEwan, Mark A Schembri. (2018) Copper ions and coordination complexes as novel carbapenem adjuvants. Antimicrobial Agents and Chemotherapy 62:e02280-17.
2017
Karrera Y Djoko*, Minh-Duy Phan, Kate M Peters, Mark J Walker, Mark A Schembri, Alastair G McEwan. (2017) Interplay between tolerance mechanisms to copper and acid stress in Escherichia coli. Proceedings of the National Academy of Sciences 114(26): 6818-6823.
James W Marsh, Karrera Y Djoko, Alastair G McEwan, Wilhelmina M Huston. (2017) Copper(II)-bis(thiosemicarbazonato) complexes as anti-chlamydial agents. Pathogens and Disease 75(7): ftx084.
Andrew G Turner, Y Ong Cheryl-lynn, Karrera Y Djoko, Nicholas P West, Mark R Davies, Alastair G McEwan, Mark J Walker. (2017) The PerR-regulated P1B-4-Type ATPase (PmtA) acts as a ferrous iron efflux pump in Streptococcus pyogenes. Infection and Immunity 85(6): e00140-17.
Andrew G Turner, Y Ong Cheryl-lynn, Mark J Walker, Karrera Y Djoko, Alastair G McEwan. (2017) Transition metal homeostasis in Streptococcus pyogenes and Streptococcus pneumoniae. Advances in Microbial Physiology 70: 123-191.
2016
Rafael M Couñago, Nathan H Chen, Chiung-Wen Chang, Karrera Y Djoko, Alastair G McEwan, Bostjan Kobe. (2016) Structural basis of thiol-based regulation of formaldehyde detoxification in Haemophilus influenzae by a MerR regulator with no sensor region. Nucleic Acids Research 44(14): 6981-6993. [LINK] [PDF]
Nathan H Chen, Karrera Y Djoko, Frédéric J Veyrier, Alastair G McEwan. (2016) Formaldehyde stress responses in bacterial pathogens. Frontiers in Microbiology 7. [LINK] [PDF]
2015
Freda E-C Jen, Karrera Y Djoko, Stephen J Bent, Christopher J Day, Alastair G McEwan, Michael P Jennings. (2015) A genetic screen reveals a periplasmic copper chaperone required for nitrite reductase activity in pathogenic Neisseria. The FASEB Journal 29(9): 3828-3838. [LINK] [PDF]
Karrera Y Djoko*, Maira M Goytia, Paul S Donnelly, Mark A Schembri, William M Shafer, Alastair G McEwan. (2015) Copper(II)-bis(thiosemicarbazonato) complexes as antibacterial agents: Insights into their mode of action and potential as therapeutics. Antimicrobial Agents and Chemotherapy 59(10): 6444-6453. [LINK]
Karrera Y Djoko, Cheryl-lynn Y Ong, Mark J Walker, Alastair G McEwan. (2015) The role of copper and zinc toxicity in innate immune defense against bacterial pathogens. Journal of Biological Chemistry 290(31): 18954-18961. [LINK]
2014
John M Atack, Ines Ibranovic, Cheryl-Lynn Y Ong, Karrera Y Djoko, Nathan H Chen, Rachel Vanden Hoven, Michael P Jennings, Jennifer L Edwards, Alastair G McEwan. (2014) A role for lactate dehydrogenases in the survival of Neisseria gonorrhoeae in human polymorphonuclear leukocytes and cervical epithelial cells. The Journal of Infectious Diseases 210(8): 1311-1318. [LINK]
Karrera Y Djoko*, Brett M Paterson, Paul S Donnelly, Alastair G McEwan. (2014) Inhibition of respiratory Complex I by copper(II)-bis(thiosemicarbazonato) complexes. Metallomics 6(12): 2250-2259. [LINK]
Karrera Y Djoko*, Brett M Paterson, Paul S Donnelly, Alastair G McEwan. (2014) Antimicrobial effects of copper(II) bis(thiosemicarbazonato) complexes provide new insight into their biochemical mode of action. Metallomics 6(4): 854-863. [LINK]
2013
Karrera Y Djoko* and Alastair G McEwan. (2013) Antimicrobial action of copper is amplified via inhibition of heme biosynthesis. ACS Chemical Biology 8(10): 2217-2223. [LINK]
Nathan H Chen, Rafael M Counago, Karrera Y Djoko, Michael P Jennings, Michael A Apicella, Bostjan Kobe, Alastair G McEwan. (2013) A glutathione-dependent detoxification system is required for formaldehyde resistance and optimal survival of Neisseria meningitidis in biofilms. Antioxidants & Redox Signaling 18(7): 743-755. [LINK]
Karrera Y Djoko, Maud ES Achard, Alastair G McEwan. (2013) Copper in immune cells. In Encyclopedia of Inorganic and Bioinorganic Chemistry. 1-11.
John M Atack, Yogitha N Srikhanta, Karrera Y Djoko, Jessica P Welch, Norain HM Hasri, Christopher T Steichen, Rachel N Vanden Hoven, Sean M Grimmond, Dk Seti Maimonah Pg Othman, Ulrike Kappler, Michael A Apicella, Michael P Jennings, Jennifer L Edwards, Alastair G McEwan. (2013) Characterization of an ntrX mutant of Neisseria gonorrhoeae reveals a response regulator that controls expression of respiratory enzymes in oxidase-positive Proteobacteria. Journal of Bacteriology 195(11): 2632-2641. [LINK] [PDF]
2012
Karrera Y Djoko, Jessica A Franiek, Jennifer L Edwards, Megan L Falsetta, Stephen P Kidd, Adam J Potter, Nathan H Chen, Michael A Apicella, Michael P Jennings, Alastair G McEwan. (2012) Phenotypic characterization of a copA mutant of Neisseria gonorrhoeae identifies a link between copper and nitrosative stress. Infection and Immunity 80(3): 1065-1071. [LINK] [PDF]
2011
Stephen P Kidd, Karrera Y Djoko, JiaQi Ng, M Pilar Argente, Michael P Jennings, Alastair G McEwan. (2011) A novel nickel responsive MerR-like regulator, NimR, from Haemophilus influenzae. Metallomics 3(10): 1009-1018. [LINK]
Alastair G McEwan, Karrera Y Djoko, Nathan H Chen, Rafael LM Couñago, Stephen P Kidd, Adam J Potter, Michael P Jennings. (2011) Novel bacterial MerR-Like regulators. In 58: 1-22. [LINK]
2010
Karrera Y Djoko, Lee Xin Chong, Anthony G Wedd, Zhiguang Xiao. (2010) Reaction mechanisms of the multicopper oxidase CueO from Escherichia coli support its functional role as a cuprous oxidase. Journal of the American Chemical Society 132(6): 2005-2015. [LINK]
Before 2010
Karrera Y Djoko, Zhiguang Xiao, Anthony G Wedd. (2008) Copper resistance in Escherichia coli: The multicopper oxidase PcoA catalyzes oxidation of copper(I) in CuICuII‐PcoC. ChemBioChem 9(10): 1579-1582. [LINK]
Simon C Drew, Karrera Y Djoko, Lianyi Zhang, Melissa Koay, John F Boas, John R Pilbrow, Zhiguang Xiao, Kevin J Barnham, Anthony G WeddG. (2008) Electron paramagnetic resonance characterization of the copper-resistance protein PcoC from Escherichia coli. Journal of Biological Inorganic Chemistry 13(6): 899-907. [LINK]
Karrera Y Djoko, Zhiguang Xiao, David L Huffman, Anthony G Wedd. (2007) Conserved mechanism of copper binding and transfer. A comparison of the copper-resistance proteins PcoC from Escherichia coli and CopC from Pseudomonas syringae. Inorganic Chemistry 46(11): 4560-4568. [LINK]
Marcus R Helfrich, Lauren K Mangeney-Slavin, M Scott Long, Karrera Y Djoko, Christine D Keating. (2002) Aqueous phase separation in giant vesicles. Journal of the American Chemical Society 124(45): 13374-13375. [LINK]
Djoko Lab 